Presentation
Gaël Ménasché received her Ph.D. from the University Pierre et Marie Curie, Paris (France) under the direction of Dr. Geneviève de Saint Basile at the Necker-Enfants malades hospital in 2004. Then, she performed her postdoctoral training in the Gary Koretzky’s lab in Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia (USA). In 2007, she joined INSERM at Imagine institute in Paris. Gaël Ménasché’s research has been focusing on molecular mechanisms underlying genetic immune disorders affecting immune homeostasis and the molecular dissection of the cytotoxic activity in lymphocytes through the study of primary hemophagocytic syndromes. This work has led to the identification of several key molecules regulating the trafficking and the docking steps of lytic granules. Based on this expertise, Gael Ménasché has progressively focused her research on regulated secretion processes and vesicular trafficking in immune cells and the genetic bases of severe allergic disorders.
Resources & publications
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Journal (source)J. Invest. Dermatol.
A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia.
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Journal (source)Br. J. Dermatol.
EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv...
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Journal (source)Br. J. Dermatol.
EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv...
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Journal (source)J. Invest. Dermatol.
Mutations in PERP Cause Dominant and Recessive Keratoderma.
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Journal (source)Mol Ther Nucleic Acids
Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Usin...
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Journal (source)Sci Transl Med
APOBEC mutation drives early-onset squamous cell carcinomas in recessive dyst...
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Journal (source)J. Invest. Dermatol.
Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Reces...
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Journal (source)J. Am. Acad. Dermatol.
Diacerein orphan drug development for epidermolysis bullosa simplex: A phase ...
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Journal (source)J. Invest. Dermatol.
Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7)...
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Journal (source)J. Invest. Dermatol.
Targeted Exon Skipping Restores Type VII Collagen Expression and Anchoring Fi...
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Journal (source)J. Invest. Dermatol.
Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bull...
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Journal (source)PLoS Genet.
KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.
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Journal (source)J. Exp. Med.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks...
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Journal (source)J Allergy Clin Immunol
Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α a...
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Journal (source)Expert Opin Emerg Drugs
Emerging drugs for the treatment of epidermolysis bullosa.
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Journal (source)J Invest Dermatol
Drug Repurposing Reveals mTOR Inhibition as a Promising Strategy for Epidermo...